Why second infection from dengue is more severe than the first infection?

Dengue is a viral infection that spreads from mosquitoes to people. It is more common in tropical and subtropical climates, where the primary vector, Aedes aegypti mosquito, thrives. Dengue can cause a range of symptoms , from mild fever and headache to severe bleeding and shock. There is no specific treatment for dengue, and prevention depends on reducing mosquito breeding and avoiding mosquito bites.

Nepal is one of the countries where dengue is endemic, meaning it occurs regularly. According to the World Health Organization (WHO ), Nepal has reported over 42,000 confirmed cases and 51 confirmed deaths due to dengue this year, affecting all seven provinces and 77 districts. This is the largest dengue outbreak in Nepal’s history, surpassing the previous record of 18,000 cases and six deaths in 2019.